Neurobiology of Disease Migraine Mutations Impair Hippocampal Learning Despite Enhanced Long-Term Potentiation
نویسندگان
چکیده
Ergin Dilekoz,1* Thijs Houben,1,2* Katharina Eikermann-Haerter,1 Mustafa Balkaya,1 A. Mariette Lenselink,4 Michael J. Whalen,5 Sabine Spijker,4 Michel D. Ferrari,2 Arn M.J.M. van den Maagdenberg,2,3 and Cenk Ayata1,6 1Neurovascular Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, Departments of 2Neurology and 3Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands, 4Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands, 5Department of Pediatric Critical Care Medicine and 6Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114
منابع مشابه
Migraine mutations impair hippocampal learning despite enhanced long-term potentiation.
To explain cognitive and memory difficulties observed in some familial hemiplegic migraine (FHM) patients, we examined hippocampal neurotransmission and plasticity in knock-in mice expressing the FHM type 1 (FHM1) R192Q gain-of function mutation in the CACNA1A gene that encodes the α1A subunit of neuronal CaV2.1 channels. We determined stimulus intensity-response curves for anterior commissure-...
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